The goal of this clinical trial is to compare the efficacy of gabapentin with loratadine in
reducing the severity of uremic pruritus in patients of chronic kidney disease and to compare
the side effects of both drugs. The main questions it aims to answer are:
- Which drug (gabapentin versus loratadine) is more effective in reducing the severity of
uremic pruritus?
- Which drug (gabapentin versus loratadine) has fewer side effects?
Participants were divided into two groups.Group A received loratadine 10mg daily and group B
received gabapentin 100mg daily. Both groups were given treatment for 4 weeks.
- Participants were asked to grade the severity of pruritus on a numerical rating scale
and also answer the Dermatology Life Quality Index Questionnaire (DLQI)
- Participants were also asked to report any side effects, if occurred.
Researchers compared both groups with regards to improvement in pruritus severity, DLQI score
and side effects.