Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy

• Status: Recruiting
• Trial end date: 2024-04-30
• Target enrollment: 0
• Participant gender: All

Summary

Gabapentin is a nerve medication that treats pain. The specific aim of the study is to compare the difference in the postoperative use of no gabapentin, 300 mg gabapentin 3x daily, or 300 mg gabapentin once at night. Our hypothesis is that higher doses of gabapentin will correlate with decreased pain at the incision and chest tube sites and decreased opioid consumption.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indiana University
• Treatments: Gabapentin

Criteria

Inclusion criteria:

• Pt undergoing open thoracotomy at Indiana University Hospital

• ASA 1,2,3 or 4

• Age 18 or older, male or female

Exclusion criteria:

• History of substance abuse in the past 6 months which would include heroin, marijuana or any other illegal street drugs

• Patient on home dose of gabapentin or pregabalin

• Patient staying intubated after surgery

• Patient above 70yo

• Patient (home dose) taking more than 30mg PO morphine equivalent (PME) per day

• Known allergy or other contraindications to the study medications, which include gabapentin

• Patient unable to receive post-op epidural

• BMI above 40

• Creatinine clearance less than 30