GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial
Status:
Not yet recruiting
Trial end date:
2027-09-30
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to determine if twice daily oral penicillin prophylaxis is
non-inferior to monthly IM penicillin prophylaxis in preventing latent Rheumatic Heart
Disease Progression in children between the ages of 5-17 years. The main objective is to
compare the proportion of children aged 5-17 years with latent RHD receiving oral penicillin
prophylaxis who progress to worse valvular disease at 2-years compared to children who
receive IM penicillin prophylaxis.
Phase:
Phase 2
Details
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Collaborator:
Uganda Heart Institute
Treatments:
Penicillin G Penicillin G Benzathine Penicillin G Procaine Penicillin V Penicillins