GDC-0980 in Combination With a Fluoropyrimidine, Oxaliplatin, and Bevacizumab in Patients With Advanced Solid Tumors

• Status: Completed
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This is an open-label, multicenter, Phase Ib, dose-escalation study designed to assess the safety, tolerability, and pharmacokinetics of oral GDC-0980 administered in combination with capecitabine and with mFOLFOX6 chemotherapy with bevacizumab added on at Cycle 5 in patients with advanced or metastatic solid tumors.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Genentech, Inc.
• Treatments: Bevacizumab; Capecitabine; Oxaliplatin

Criteria

Inclusion Criteria:

• Histologically or cytologically documented locally advanced or metastatic solid tumors for which established therapy is ineffective, not tolerable, or does not exist

• Patients with histologically or cytologically documented locally advanced or metastatic breast cancer who have received at least one prior chemotherapy-based regimen for incurable disease (Arm A)

• Patients with histologically or cytologically documented locally advanced or metastatic CRC who have not received prior oxaliplatin-based therapy within 1 year of initiation of study treatment. (Arm B)

Exclusion Criteria:

• Prior anti-cancer therapy that fulfills the following criteria: a total of more than six courses of an alkylating agent, a total of more than four courses of carboplatin-containing chemotherapy regimens, and a total of more than two courses of nitrosoureas or mitomycin C, high-dose chemotherapy requiring stem-cell support, and irradiation to >= 25% of bone marrow-bearing areas

• Current dyspnea at rest because of complications of advanced malignancy or other disease requiring continuous oxygen therapy

• Known deficiency of dihydropyrimidine dehydrogenase (DPD)

• Bisphosphonate therapy for symptomatic hypercalcemia

• Known untreated or active central nervous system (CNS) metastases

• Pregnancy, lactation, or breastfeeding

For Arm B:

• Inadequately controlled hypertension

• Prior history of hypertensive crisis or hypertensive encephalopathy

• History of myocardial infarction or unstable angina within 6 months prior to the first dose of study treatment

• History of stroke or transient ischemic attacks within 6 months prior to the first dose of study treatment

• Significant vascular disease within 6 months prior to the first dose of study treatment

• History of hemoptysis within 1 month prior to the first dose of study treatment

• Patients with one or more pulmonary tumor masses with evidence of cavitation

• Evidence of bleeding diathesis or significant coagulopathy

• Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to the first dose of study treatment

• History of abdominal fistula, GI perforation, or intra-abdominal abscess within 6 months prior to the first dose of study treatment

• Clinical signs or symptoms of GI obstruction or requirement for parenteral hydration, parenteral nutrition, or tube feeding

• Evidence of abdominal free air not explained by paracentesis or recent surgical procedure

• Serious, non-healing wound, active ulcer, or untreated bone fracture

• The presence of an ulcerating breast cancer tumor will not render a patient ineligible

• Proteinuria