Overview

GA In NEwly Diagnosed Diffuse Large B Cell Lymphoma

Status:
Terminated
Trial end date:
2017-12-31
Target enrollment:
Participant gender:
Summary
This study is designed to investigate: - the interest of a new monoclonal antibody (GA101)versus rituximab - the interest of PET to identify early responders Patients will receive either rituximab (standard treatment), either GA101 (study treatment), according to the randomization arm. The monoclonal antibody will be associated to a chemotherapy: CHOP or ACVBP according to site's choice.A PET scan will be done before inclusion, after 2 chemotherapy cycles, and after 4 chemotherapy cycles, to identify early patients responders, for who consolidation with ASCT is not required.
Phase:
Phase 3
Details
Lead Sponsor:
The Lymphoma Academic Research Organisation
Collaborator:
Hoffmann-La Roche
Treatments:
Bleomycin
Cyclophosphamide
Doxorubicin
Obinutuzumab
Prednisone
Rituximab
Vincristine