G-CSF and Erythropoetin in Survival of Patients With Decompensated Liver Disease
Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
Study Design
50 patients will be enrolled and randomized into patients (Group IA) and controls (Group I B)
Investigations:
Hematology CBC, Prothrombin time and INR Peripheral smear, Retics Biochemistry Liver function
testing, AFP Kidney function testing Etiology of chronic liver disease Infectious etiology:
total antiHBc, anti HCV, HCV RNA, HBV DNA Non infectious etiology: Autoimmune markers, copper
studies, iron studies, HOMA IR, FBS Etiology of decompensation Variceal bleed Infection (
blood culture, urine culture, sputum culture, chest xray) Surgery Drugs Alcohol intake
Ascitic fluid analysis UGI endoscopy Imaging USG abdomen with Doppler for spleno-portal axis
CECT- Triple phase upper abdomen Liver regenerative potential efficacy testing Histology ( by
transjugular liver biopsy) Liver Dendritic cells ( CD11c, CD40, CD 54, CD 123, BDCA 2
staining) by flow cytometry CD 34+ cells, CD 45+ cells and CD 133+ cells measurement in
hepatic venous blood, peripheral blood and liver biopsy by flow cytometry Markers of
proliferation like Ki- 67, proliferating cell nuclear antigen (PCNA) in liver biopsy Markers
of angiogenesis like VEGF, v WF in hepatic venous blood Measurement of Hepatic venous
pressure gradient ( HVPG)