Furosemide and Creatinine Tubular Stress Test in Order to Measure Proximal Tubule Residual Function
Status:
Recruiting
Trial end date:
2022-07-01
Target enrollment:
Participant gender:
Summary
This is a two phase study. The first part will take place at the National Institute of
Cardiology in Mexico, the second phase will be made in collaboration with the University of
California San Diego.
This is a non blind experimental study, 60 patients with different stages of CKD from the
outpatient unit of the institute will be included. Each patient will receive a furosemide
stress test of 1 mg/kg in non diuretic users and 1.5 mg/kg in diuretic users, in addition to
an oral load of 5 grams of creatinine, as well as Iohexol to measure GFR. After the
intervention blood and urine samples will be drawn at 10 minutes, 30 minutes, and every hour
until the completion of the observation at 6 hours.
Blood and urine will be analized to measure creatinine (blood and urine), then samples will
be processed for measurement of furosemide (mass spectometry), indoxyl sulphate, p-cresol,
hippurate, and uromoduline.
The aim of this stiudy is to asses the differences between GFR and proximal tubule function.