The research plan proposes to develop translational studies in humans that will identify host
susceptibility factors that confer vulnerability to the prototypal air pollutant, ozone.
Ozone is a ubiquitous urban air pollutant and associated with increased emergency room
visits, and co-associates with other air pollutants, to increase mortality in high risk
groups (cardio-pulmonary disease) of the population.The results will have significant impact
upon and aid in understanding mechanisms of pro-oxidant lung injury, airway
hyperresponsiveness, and adverse health effects, that occur during and following exposure to
inhalable airborne irritants.
Details
Lead Sponsor:
National Institute of Environmental Health Sciences (NIEHS)