Functional Dyspepsia - Effect of Acid-Reducing Treatment and Information.
Status:
Terminated
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
Study title: Functional dyspepsia -- effect of acid reducing treatment and individualized
information.
Summary: 15-20% of all people experience dyspepsia each year. Dyspepsia means pain or
discomfort in the upper part of the abdomen. Accompanying symptoms from the esophagus may be
present. The most important relevant medical examination is gastroscopy, and if the findings
are normal the condition is usually classified as functional dyspepsia.
Several disturbances of function are now known as potential causes of such symptoms, and the
optimal choice of treatment may vary.
In the study the investigators plan to examine whether different types of functional
disturbances respond differently to medical therapy. In particular, the investigators want to
assess whether comprehensive and individualized information will influence the results of
therapy. This has not been previously studied systematically.
The investigators also postulate that disturbances of function of the esophagus may cause
complaints that should be classified as functional dyspepsia even if the symptoms are
atypical. Few studies have been done to evaluate this hypothesis, and there may be potential
consequences for choice of appropriate treatment.
In animal models and in humans is recently demonstrated that elevated gastric pH because of
anti-ulcer treatment can trigger food allergy. We use a proton pump inhibitor in our study
and eventually development of food allergy will influence patient's condition in an
observations period. That why we're observing IgE dynamics in our study.