Overview

Frontline Clinician Psilocybin Study

Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
0
Participant gender:
All
Summary
We aim to investigate the effects of a single dose of psilocybin, delivered in the context of pre- and post-dose psychotherapy, on symptoms of depression and burnout suffered by healthcare clinicians as a result of frontline work in the coronavirus disease of 2019 (COVID) pandemic.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Washington
Treatments:
Psilocybin
Criteria
Inclusion Criteria:

1. Participants must be physicians or nurses with at least 1 month of frontline clinical
experience during the COVID pandemic who rate at least 2 of 4 items from the COVID
Exposure index as 'more than half the days' during their peak 2 week period of
exposure: i. Caring for someone critically ill with COVID-19, or who became critically
ill while you were involved; ii. Working longer hours than usual in order to provide
assistance or care to individuals with COVID-19; iii. Witnessing or responding to a
death related to COVID-19, or losing a patient you had been caring for to COVID-19;
iv. Caring for patients who have died without family physically present due to
COVID-19 precautions

2. Have a Montgomery-Asberg Depression Rating Scale (MADRS) clinician-administered
depression score >21, indicating moderately severe symptoms.

3. Have had persistent symptoms despite at least one medication and/or therapy trial of
standard care treatment for depression.

4. English speaking - able to understand the process of consent and the risk and benefits
associated with the study, and able to give written informed consent.

5. Must be willing to sign a medical release for the investigators to communicate
directly with their therapist and doctors to confirm a medication and/or medical
history. This is decided on a case-by-case basis upon the discretion of the PI.

6. Must be driven home after the medication dosing session by a driver (which could be a
friend, family, rideshare or taxi).

7. Must provide at least one adult to have continuous contact with the participant,
provide participant transportation, monitor changes in the participant's behavior, and
notify research staff of behavior changes.

8. Has been off selective serotonin inhibitors (SSRIs) for at least five half-lives of
the drug plus 2 weeks.

9. Must avoid taking any psychiatric medications or starting a new psychiatric medication
during the study. Should participant's doctor recommend starting a new psychiatric
medication, participant will be required to notify the study team and the subject
would withdraw from the study

10. Must provide a contact (relative, spouse, close friend or other caregiver) who is
willing and able to be reached by the Clinical Investigators in the event of a
participant becoming suicidal.

11. If able to bear children, must have a negative pregnancy test at study entry.

12. Are willing to commit to preparation sessions, medication dosing sessions, integration
sessions, to complete evaluation instruments and commit to be contacted for all
necessary telephone contacts.

Exclusion Criteria:

1. Personal or immediate family history of schizophrenia, bipolar affective disorder,
delusion disorder, paranoid disorder, or schizoaffective disorder.

2. Suicidal ideation with a Columbia Suicide Severity Rating Scale (C-SSRS) > 3

3. Current substance abuse disorder (except in the case of mild alcohol use )

4. Neuroleptic and SSRI medications that cannot be tapered and discontinued in
conjunction with the participant's prescribing physician.

5. Unstable neurological or medical condition; history of seizure, chronic/severe
headaches.

6. Positive urine pregnancy test at the time of screening

7. Any unstable medical condition that my render study procedures unsafe.

8. Any use of psychedelic drugs within the prior 12 months.

9. Use of tramadol, due to the potential for serotonin syndrome with concomitant use of
psilocybin.