Frequency of Sleep Abnormalities in Patients With Irritable Bowel Syndrome and Effect of Pharmacological Intervention
Status:
Recruiting
Trial end date:
2022-02-01
Target enrollment:
Participant gender:
Summary
Irritable bowel syndrome (IBS), a common gastrointestinal (GI) disorder in India and in the
rest of the World, is enigmatic in its pathogenesis. IBS is associated with recurrent
abdominal pain or discomfort, bloating, incomplete evacuation, altered bowel habits, and
abnormal stool forms. The etiology of IBS remains unclear and different factors were thought
to be involved like genetics and environmental factors, visceral hypersensitivity, altered
gut microbiota or disorder of the microbiota-gut-brain axis and various psychological factors
like anxiety, depression, and insomnia or sleep disturbance. Due to increasing work pressure
in today's society, and the consequent shift duty and psychological stress, the frequency of
sleep disorders is increasing; disturbed sleep may be associated with a vicious cycle in
which altered sleep may result in gastrointestinal (GI) disturbances, which in turn, may
jeopardize sleep further. The disorder of the gut microbiota, the largest organ of the human
body, is being suggested to be responsible for several GI and extra-GI diseases. Qualitative
change in gut microbiota is currently studied by next-generation sequencing. Gut and sleep
patterns work in an axis - a two-way street of communication, some studies reported altered
gut microbiota or dysbiosis modulates peripheral and central nervous system function, leading
to alterations in brain signaling and behavior that possibly leads to sleep disturbances.
Phase:
Phase 3
Details
Lead Sponsor:
Sanjay Gandhi Postgraduate Institute of Medical Sciences