Free Fatty Acids and Vascular Function in Subjects With Diabetes

• Status: Completed
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will test the hypothesis that reduction in release of free fatty acids from adipocytes will restore insulin-mediated endothelium-dependent vasodilation and skeletal muscle glucose metabolism in subject with type 2 diabetes.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brigham and Women's Hospital
• Treatments: Acipimox

Criteria

Inclusion Criteria:

• type 2 diabetes mellitus (as defined by the National Diabetes Data Group)

• normal cardiovascular exam

• non smoker (for 1 year prior to entry)

• Healthy volunteers

• no known medical problems

• normal cardiovascular exam

• fasting glucose < 110 mg/dL

• non-smoker (for 1 year prior to entry)

Exclusion Criteria:

Type 2 Diabetics

• untreated hypertension (>140/90 mmHg)

• untreated hypercholesterolemia (LDL > 75th percentile for age)

• cigarette smoking within 1 year

• neuropathy requiring medication

• nephropathy (> 300mg/24 hour urinary albumin, or serum creatinine > 1.4 mg/dL

• abnormal cardiovascular exam

• treatment with thiazolidinedione within 1 year

• post-menopausal women taking hormone replacement therapy

(Note: subjects taking angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) must stop these medications for 2 weeks prior to taking study drug. If blood pressure rises to >140/90, subjects will be prescribed an alternative medication or be withdrawn from the study.

Healthy Volunteers

• abnormal cardiovascular exam

• use of prescription medications

• fasting glucose > 110mg/dL

• cigarette smoking within 1 year