Overview
Four-period Crossover Study to Assess the Effects of Single Oral Doses of ZD4054 (Zibotentan) (10mg and 30mg) on QTc Interval
Status:
Completed
Completed
Trial end date:
2008-11-01
2008-11-01
Target enrollment:
0
0
Participant gender:
Male
Male
Summary
This Study compares two ZD4054 (Zibotentan) doses (10mg and 30mg) with a placebo and a positive control to look at ZD4054 (Zibotentan)'s effect on the ECG of Healthy VolunteerPhase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
AstraZenecaTreatments:
Fluoroquinolones
Moxifloxacin
Norgestimate, ethinyl estradiol drug combination
Criteria
Inclusion Criteria:- Non Smoker
- Normal resting 12-lead ECG with normal QTc interval (<450 msec)
- Negative screens for serum hepatitis B surface antigen, hepatitis C antibody and Human
Immunodeficiency Virus (HIV) at screening
Exclusion Criteria:
- Receipt of another new chemical entity in the 4 months before dosing in this study;
participation in another study and participation in a non-invasive methodology study
in which no drugs were given within 30 days before dosing in this study
- Risk (in the investigator's opinion) of transmitting, through blood or other body
fluids, the agents responsible for acquired immune deficiency syndrome (AIDS),
hepatitis B or hepatitis C
- Judgement by the investigator, that the healthy volunteer should not participate in
the study