Foscan®-Mediated Photodynamic Therapy Versus Brachytherapy in Patients With Nasopharyngeal Carcinoma
Status:
Unknown status
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
Objectives:
Primary objective
- To determine the efficacy of Foscan-PDT compared with Brachytherapy for recurrent or
persistent NPC, as determined by macroscopic clinical examination, CT scan and biopsy. The
primary endpoint is complete tumour response at 6 months.
Secondary objective:
- To determine the response rates, e.g. presence of tumour on endoscopy, time to
progression and overall survival in patients treated with Foscan-PDT compared with
brachytherapy
- To determine the quality of life, as derived from the University of Washington Quality
of Life questionnaire in patients treated with Foscan-PDT compared with brachytherapy
- To evaluate the safety of Foscan-PDT compared with brachytherapy in terms of adverse
events and serious adverse events.