For Prevention of Diarrhea in Patients Diagnosed With Metastatic Colorectal Cancer Treated With Chemotherapy
Status:
Terminated
Trial end date:
2003-01-01
Target enrollment:
Participant gender:
Summary
The Diarrhea Prevention with an investigational drug trial, will evaluate whether adding an
investigational drug to the standard treatment for advanced colorectal cancer can reduce the
amount of diarrhea a patient experiences. The standard and approved treatment for patients
with metastatic colorectal cancer is repeated cycles of chemotherapy consisting of a
combination of irinotecan (also known as CPT-11, Camptosar), 5-fluorouracil (also known as
5FU), and leucovorin (also known as LV). Preclinical data from animal models suggest that the
investigational drug may offer an effective means for preventing CPT-11/5FU/LV-induced
diarrhea. It is also hypothesized that the investigational drug-mediated anti-angiogenesis
could induce a favorable tumor response.