Foley Catheter Versus PGE2 for Labor Induction at Term: a Pilot Study
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
Induction of labor is one of the most common interventions in obstetrics. In the past decade,
the rates of labor induction at term have doubled from approximately 9% to 23% in the United
States and from 10% to 20.4% in China. The majority of women undergoing labor induction
requires cervical ripening for the unfavorable cervixes. As globally, it is still required to
explore an optimal induction method. Foley catheter was among the oldest mechanical
approaches, while prostaglandin E2 vaginal suppository (PGE2) one of the most popular
pharmacological agents for cervical ripening. There were studies reporting similar cesarean
section rates between these two methods. However, there are no randomized control trials
(RCTs) with adequate power to compare their frequencies of severe perinatal complications.
The investigators aim to compare the effectiveness and safety of Foley catheter versus PGE2
for induction of labor among term pregnant women with an unfavourable cervix.