Fluorouracil and Leucovorin and/or Levamisole After Surgery In Treating Patients With Dukes' B Or Dukes' C Colon Cancer
Status:
Completed
Trial end date:
2004-04-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Leucovorin may help fluorouracil kill more tumor cells. Biological therapies, such as
levamisole, may interfere with the growth of tumor cells and slow the growth of solid tumors.
It is not yet known whether fluorouracil is more effective when given together with
leucovorin and/or levamisole after surgery in treating colon cancer.
PURPOSE: This randomized phase III trial is studying giving fluorouracil together with
leucovorin to see how well it works compared with giving fluorouracil together with
levamisole, or giving fluorouracil together with leucovorin and levamisole after surgery in
treating patients with Dukes' B or Dukes' C colon cancer.
Phase:
Phase 3
Details
Lead Sponsor:
NSABP Foundation Inc
Collaborators:
National Cancer Institute (NCI) Northern California Cancer Center