Fluorouracil Plus Radiation Therapy Following Surgery in Treating Patients With Pancreatic Cancer

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells left after surgery.

PURPOSE: Phase II trial to study the effectiveness of combining fluorouracil and radiation therapy in treating patients who have undergone surgery for pancreatic cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: GERCOR - Multidisciplinary Oncology Cooperative Group; Groupe Cooperateur Multidisciplinaire en Oncologie (GERCOR)
• Treatments: Fluorouracil

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed pancreatic adenocarcinoma

• Complete macroscopic resection of tumor within past 30 days

• No residual visceral or peritoneal metastasis

• Involvement of Vater's ampulla or extrahepatic bile duct allowed

• No vesicular or intrahepatic cholangiocarcinomas

PATIENT CHARACTERISTICS:

Age:

• 18 to 75

Performance status:

• ECOG 0-2

Life expectancy:

• Not specified

Hematopoietic:

• Absolute neutrophil count greater than 1,500/mm^3

• Platelet count greater than 100,000/mm^3

Hepatic:

• Alkaline phosphatase less than 3 times normal

• Bilirubin less than 1.5 times normal

Renal:

• Creatinine less than 1.5 times normal

Cardiovascular:

• No serious cardiac failure

Pulmonary:

• No serious respiratory failure

Other:

• No other untreatable malignant tumors

• No serious psychological, familial, social, or geographical conditions that would preclude study

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• No prior chemotherapy for pancreatic adenocarcinoma

Endocrine therapy:

• Not specified

Radiotherapy:

• No prior radiotherapy for pancreatic adenocarcinoma

• No prior radiotherapy in an anatomically proximal region to treatment area

Surgery:

• See Disease Characteristics