Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses
Status:
Not yet recruiting
Trial end date:
2024-06-30
Target enrollment:
Participant gender:
Summary
This study will evaluate fluoride (F) bioavailability in saliva when using an
over-the-counter mouthrinse of 226 ppm F, immediately after brushing with an over-the-counter
toothpaste of 1,100 ppm F or a prescription toothpaste of 5,000 ppm F. The study population
will include twenty individuals, over the age of 18 years-old, from both genders, with normal
oral health conditions and salivary flow rate, no need of urgent dental needs, from the Ann
Arbor, MI area. Participants will be recruited from the University of Michigan School of
Dentistry, in Ann Arbor, MI. Using a crossover design, twenty participants will be rotating
through 4 different combinations of fluoride toothpaste (over-the-counter or prescription
concentration) and fluoride mouth rinse (yes or no), in a 2 x 2 factorial design. Treatments
to be tested will be as followed: Group #1 will brush with 1,100 ppm F (over-the-counter)
toothpaste; Group #2 will brush with 1,100 ppm F (over-the-counter) toothpaste and rinse with
over-the-counter 226 ppm F mouthrinse; Group #3 will brush with 5,000 ppm F (prescription)
toothpaste; Group #4 will brush with 5,000 ppm F (prescription) toothpaste and rinse with
over-the-counter 226 ppm F mouthrinse.