Fluoride Controlled-release System for Initial Lesions of Caries
Status:
Completed
Trial end date:
2018-12-12
Target enrollment:
Participant gender:
Summary
OBJECTIVE: To evaluate in vivo the efficacy of fluoride-containing dentifrice incorporated in
a controlled-release system (F-CSL, patent pending) in the remineralization of white spot
lesions of caries in caries-active individuals. METHODS: A double-blind randomized clinical
trial to evaluate the bioavailability of intraoral fluoride in biomarkers of exposure
(biofilm and saliva) after the use of experimental toothpaste in the control of dental
caries. The study will last three months. The participants of the study will be divided into
three groups according to the dentifrice used. The sample will be selected randomly and
composed of children and adolescents who seek the service of cariology of the UFPB. There
will be participants of both sexes, preferably of the metropolitan region of João Pessoa in
order to guarantee the low fluorine exposure by the water of supply. Intrabucal photographs
will be obtained. Samples of saliva will be collected after 3 hours of the last meal. The
benefits will be achieved by obtaining the reduction of the white spot area (mm2) plus the
fact that all the children will be examined and will receive information on the treatment
needs and forwading for the same.