A current gap in the use indocyanine green fluorescence to isolate the biliary system is the
dosing amount necessary to fluoresce the biliary system without "over" fluorescing the liver
and gallbladder. Over fluorescing surrounding structures such as the liver and gallbladder
saturates the image and makes it impossible to identify biliary leaks or differentiate
branches of the common bile duct using fluorescent imaging devices. The over dosing does not
affect the standard of care procedure, but eliminates the added benefit of the fluorescent
imaging technology. The use of "microdoses" (approximately 0.1 mg) of indocyanine green has
been trialed and shown promise in some patients. This study aims to do an in depth study
utilizing the Cancer goggle systems fluorescent imaging system to determine the correct dose
needed to isolate the biliary system without over fluorescing surrounding structures. This
dosing study could additionally serve as a pilot study for follow on research using
indocyanine green and fluorescent imaging in hepatobiliary surgery.