Balanced solutions with low chloride concentration could represent an alternative to high
chloride concentration solutions. Such balanced solutions contain other acid as buffers (i.e.
acetate and/or gluconate). However, acetate has been associated with alteration of cardiac
function when used as buffer in dialysate when high acetate concentrations are used and could
promote the development of metabolic acidosis if it accumulates. Therefore, the safety of
such solutions remains poorly explored. Because critically ill patients receive large amount
of fluid during the early phase of resuscitation, large amount of acetate are to be
administrated if such solutions are used. While acetate-containing solutions have been
suggested to be safe in this setting, studies are still lacking regarding clearance and
accumulation in critically ill patients.
It is expected to include 28 patients, the objective to analyze the data of 20 patients.