Fluid Challenge and Plasma Volume, During Surgery

• Status: Not yet recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml/kg body weight, albumin 5% 4 ml/kg body weight or albumin 20% 1 ml/kg body weight), using hemoglobin as a dilution indicator.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Joachim Zdolsek

Criteria

Inclusion Criteria:

• Written consent to participate in the study

• For women: relevant contraceptive, menopausal or a negative pregnancy test.

• ASA category I to III

• Laparoscopic abdominal surgery, with a duration of at least 90 minutes.

• 18 to 80 years

Exclusion Criteria:

• Patients with known cardiac failure

• <18 or >80 years

• known allergy to albumin

• extracellular hyperhydration or hypervolemia

• kidney failure

• pregnancy or planned pregnancy