Flat and Circadian Insulin Infusion Rates in Continuous Subcutaneous Insulin Infusion

• Status: Completed
• Trial end date: 2018-11-09
• Target enrollment: 0
• Participant gender: All

Summary

Randomised controlled trial to contribute to the evidence base for the optimal initial insulin profile for adults with type 1 diabetes commencing insulin pump therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Imperial College London
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Adults ≥18 years of age

• Diagnosis of T1DM for > 1 year

• On MDI with decision made to commence CSII

• Structured education in previous 3 years

• HbA1c ≤ 75mmol/mol (9%)

• Stimulated c-peptide <200pmol/L

• No severe hypoglycaemia (defined as needing 3rd party assistance) in previous year

Exclusion Criteria:

• Previous CSII

• Night or shift worker

• Recurrent severe hypoglycaemia

• Pregnant or planning pregnancy

• Breastfeeding

• Enrolled in other clinical trials

• Have active malignancy or under investigation for malignancy

• Addison's Disease

• Gastroparesis

• Autonomic neuropathy

• Concomitant use of GLP-1 analogues and gliptins

• Visual impairment

• Reduced manual dexterity