'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug
Status:
Completed
Trial end date:
2020-12-30
Target enrollment:
Participant gender:
Summary
Introduction Treatment of neuropathic pain has been a goal of numerous research projects for
the last half century, with overall disappointing results. These poor achievements are in
contrast with substantial advancements in the understanding of pain mechanisms, and numerous
molecules developed to tackle them. The need to better identify patients likely to respond to
treatment comes from the neuropathic pain experts in regards to the pharmacological domain.
The basic assertion of this project is that the pain modulation profile is altered in pain
patients toward a pro-nociceptive mode, and that the specific single or multiple dysfunctions
of pain modulation that underlie this pro-nociceptivity should be targeted by therapeutic
lines that can reverse the modulation back toward eu-nociceptivity.
The aim of this amendment is to demonstrate that pain treatment efficacy for painful diabetic
neuropathy can be optimized by individualizing pharmacological treatment choice along 'fix
the dysfunction' concept