Fisetin to Improve Physical Function in Postmenopausal Stage I-III Breast Cancer Survivors
Status:
Not yet recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
This phase II trial tests whether fisetin works to improve physical function in
postmenopausal women who have received chemotherapy for stage I-III breast cancer treatment.
Fisetin is a naturally occurring substance that is found in strawberries and other foods.
Fisetin eliminates cells that have undergone a process called senescence. Senescence is when
a cell ages and permanently stops dividing but does not die. Over time, large numbers of
these cells build up in tissues throughout the body and can release harmful substances that
causes inflammation and damages nearby healthy cells. Studies have shown that chemotherapy
causes a build-up of these senescent cells. Giving fisetin may eliminate senescent cells and
improve physical function in postmenopausal women who have received chemotherapy for breast
cancer.