Overview

First-line Treatment With Camrelizumab + Apatinib Versus Chemotherapy + Bevacizumab in Advanced Cervical Cancer

Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
0
Participant gender:
Female
Summary
Cervical cancer is the second-most common cancer in the world and is a leading cause of cancer death among women in developing countries. Cisplatin-based chemotherapy +/- bevacizumab have been recommended as the first-line treatment for patients who present with metastatic (e.g. stage IVB), persistent, or recurrent cervical cancer. However, patients in this setting are rarely curable. The immune checkpoint inhibitor (ICI) therapy, including cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed death-1 (PD-1), and programmed death-ligand 1 (PD-L1) inhibitors, has revolutionized the treatment of several cancers. The investigator previously reported the promising antitumor efficacy of camrelizumab (PD-1 inhibitor) combined with apatinib (VEGFR2 inhibitor) as second-line, or later, therapy in patients with advanced cervical cancer. This randomized study is to assess the efficacy and safety of first-line treatment with camrelizumab plus apatinib compared to the efficacy and safety of paclitaxel and cisplatin/carboplatin plus bevacizumab in patients with stage IVB, recurrent, or persistent cervical cancer.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Sun Yat-sen University
Treatments:
Apatinib
Bevacizumab
Carboplatin
Paclitaxel
Criteria
Inclusion Criteria:

- Signed Informed Consent Form (ICF)

- Age ≥ 18 years and ≤ 70 years

- Patients must have primary stage IVB, recurrent or persistent squamous cell carcinoma
of the cervix which has not been treated with systemic chemotherapy and is not
amenable to curative treatment with surgery and/or radiation therapy NOTE: Prior
adjuvant therapy is NOT counted as a systemic chemotherapeutic regimen for management
of recurrent, persistent or metastatic carcinoma of the cervix; adjuvant therapy
includes cisplatin given concurrent with primary radiation therapy (CCRT) and adjuvant
chemotherapy given following the completion of concurrent chemotherapy and radiation
therapy

- Patients must have measurable disease per RECIST v1.1; measurable lesions are defined
as those that can be accurately measured in at least one dimension (longest diameter
to be recorded as ≥ 10 mm with computed tomography (CT) scan, magnetic resonance
imaging (MRI); a lymph node must be ≥ 15 mm in short axis. Tumors within a previously
irradiated field will be designated as "non-target" lesions unless progression is
documented or a biopsy is obtained to confirm persistence at least 90 days following
completion of radiation therapy.

- Life expectancy exceeds 12 weeks.

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

- Has the ability to swallow pills

- Provide cervical cancer tissue (archival or fresh biopsy specimen) prior to
randomization for PD-L1 immunohistochemistry (IHC) testing by central laboratory

- Has PD-L1 IHC CPS ≥ 1 by central laboratory testing

- Has adequate organ function

- Female participants must not be pregnant, not breastfeeding. Female participants of
childbearing potential should be willing to use one acceptable contraception (i.e.,
oral contraceptives, contraceptive injections, contraceptive implants, spermicides,
condoms, intrauterine devices [IUDs]) during the treatment period and for 180 days
following the end

Exclusion Criteria:

- Has an active autoimmune disease that has required systemic treatment; replacement
therapy is not considered a form of systemic treatment.

- Concurrent medical condition requiring the use of immunosuppressive medications, or
immunosuppressive doses of systemic or absorbable topical corticosteroids. Doses > 10
mg/day prednisone or equivalent are prohibited within 2 weeks before study drug
administration.

- Has known active central nervous system (CNS) metastases and/or carcinomatous
meningitis;

- Has pleural effusion and ascites that require punctured and drained. However, an
exception includes patients with pleural effusion and ascites who have no symptoms.

- Has bilateral hydronephrosis which cannot be alleviated by ureteral stents or
percutaneous drainage. Ureteral stent placement must be performed in patients with
unilateral hydronephrosis prior to enrollment.

- Patients with a prior invasive malignancy who have had any evidence of disease within
the last 5 years. Exceptions include basal cell carcinoma of the skin, squamous cell
carcinoma of the skin, or in situ cervical cancer that has undergone potentially
curative therapy.

- Clinically significant cardiovascular diseases, including but not limited to
congestive heart failure (New York heart association (NYHA) class > 2), unstable or
severe angina, severe acute myocardial infarction, or cardiac arrhythmia requiring
medical intervention within 6 months before enrollment.

- Prior or concurrent diagnosis of idiopathic pulmonary fibrosis, interstitial
pneumonia, pneumoconiosis, radiation pneumonitis, and active pneumonia detected by CT
during the screening period.

- Hypertension that can not be well controlled through antihypertensive drugs (systolic
pressure ≥ 140 mm Hg and/or diastolic pressure ≥ 90 mm Hg)

- Proteinuria ≥ (++) or 24 hours total urine protein > 1.0 g.

- Patients have coagulation abnormalities with a tendency to bleed or are receiving
thrombolytic or anticoagulant therapy. Prophylactic use of aspirin (≤100mg/d),
low-molecular-weight-heparin (≤40mg/d), and Rivaroxaban is permitted.

- Any hemorrhage or bleeding event ≥ CTCAE Grade 2 within 4 weeks prior to the first
dose of study intervention;

- Arterial thrombus or phlebothrombosis within 6 months prior to randomization.

- Gastrointestinal fistula, bladder/ureteral fistula, or intestinal obstruction within 6
months prior to randomization

- Has radiation-induced enteritis within 12 months prior to randomization

- Has received anticancer treatment, including but not limited to radiotherapy,
chemotherapy, and surgery within 4 weeks before the first dose of study intervention

- Any unresolved toxicities (i.e., ≤ Grade 1 or at baseline) from prior therapy, with
exception of alopecia;

- Has an active infection requiring systemic therapy or baseline white blood cells >1.5
× 10 9 / L;

- Has known active hepatitis B disease (hepatitis B virus [HBV] DNA > 500 IU/ml 1000
copies/ml) or hepatitis C disease;

- Received prior therapy with an anti-PD-1, anti-PD-L1, or anti-CTLA-4 antibody,
apatinib, and bevacizumab.

- Has a known history of human immunodeficiency virus (HIV) infection;

- Pregnant or breastfeeding.

- According to the judgement of the researchers, there are other factors that may lead
to the termination of the study.