First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition
Status:
Active, not recruiting
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
Children with severe malnutrition who are admitted sick to hospitals have a high
mortality(death rate), usually because of infection. All children with severe malnutrition
admitted to hospitals are treated with antibiotics(medication used to kill bacteria).
However, the current antibiotics used in hospitals may not be the most effective. It is
possible that the antibiotics that are currently used after initial antibiotics should be
used first. No studies have been carried out to determine if the current antibiotics used for
treating malnourished children who are sick and admitted in hospital are the most
appropriate. The aim of this study is to find out if a changed antibiotic system for children
with malnutrition is safe, reduces the risk of death and improves nutritional recovery.
Phase:
Phase 3
Details
Lead Sponsor:
University of Oxford
Collaborators:
Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya Coast General Hospital, Mombasa, Kenya KEMRI-Wellcome Trust Collaborative Research Program KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya. Kenya Medical Research Institute London School of Hygiene & Tropical Medicine, UK. London School of Hygiene and Tropical Medicine Mbagathi Hospital, Nairobi, Kenya Mbale Regional Referral Hospital, Mbale, Uganda Swansea Trials Unit Swansea Trials Unit, Swansea University Medical School, Swansea, UK. University College London, UK. University College, London
Treatments:
Anti-Bacterial Agents Anti-Infective Agents Antibiotics, Antitubercular Ceftriaxone Gentamicins Metronidazole Penicillin G Penicillin G Benzathine Penicillin G Procaine Penicillins