Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma
Status:
Completed
Trial end date:
2013-04-01
Target enrollment:
Participant gender:
Summary
Primary Aim: To determine the feasibility and safety of hypotensive resuscitation for the
early treatment of patients with traumatic shock compared to standard fluid resuscitation.
Primary Hypotheses: The null hypothesis regarding feasibility is that hypotensive
resuscitation will result in the same volume of early crystalloid (normal saline) fluid
administration compared to standard crystalloid resuscitation. The null hypothesis regarding
safety is that hypotensive resuscitation will result in the same percent of patients
surviving to 24 hours after 911 call received at dispatch compared to standard fluid
resuscitation. Early resuscitation is defined as all fluid given until 2 hours after arrival
in the Emergency Department or until hemorrhage control is achieved in the hospital,
whichever occurs earlier.
Phase:
Phase 2
Details
Lead Sponsor:
University of Washington
Collaborators:
Canadian Institutes of Health Research (CIHR) National Heart, Lung, and Blood Institute (NHLBI)