Fibrinogen Concentrate in Isolated Traumatic Brain Injury
Status:
Unknown status
Trial end date:
2020-01-21
Target enrollment:
Participant gender:
Summary
Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation
factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be
formed with the appropriate firmness. In severe traumatic brain injury(TBI) patients, plasma
fibrinogen concentrations decrease earlier and more frequently than other coagulation
factors,predicting massive bleeding and death.
The purpose of this study is to try early injection of fibrinogen concentrate in severe
isolated traumatic brain injury and investigation the effect of it on post bleeding and
complications.