Patients with acute coronary syndromes (ACS) are at increased risk for acute kidney injury
(AKI) when they undergo urgent/emergency coronary angiography.
The optimal medical treatment for preventing the occurrence of contrast induced - acute
kidney injury is still controversial.
Fenoldopam mesylate is a dopamine A1 receptor agonist that augments renal plasma flow that
has reduced the risk of radiocontrast dye nephropathy in some (but not all) preliminary
studies.
Neutrophil gelatinase-associated lipocalin (NGAL) is a new biomarker predictive for AKI
already shown to be useful for earlier diagnosis of contrast induced nephropathy.
The primary objective of this study is to to test the hypothesis that fenoldopam, in addition
to standard treatment, reduce the occurrence of contrast induced - acute kidney injury in
patients with acute coronary syndrome (ACS) undergoing urgent/emergency coronary angiography
and/or percutaneous coronary intervention.