Fecal Microbiota Transplantation for Ulcerative Colitis

• Status: Recruiting
• Trial end date: 2030-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Fecal microbiota transplantation (FMT) is a strategy that infuses a fecal suspension containing a healthy donor's microbiota into a patient's gut to restore his/her intestinal microbiome. Fecal microbiota transplantation has been used for several disease，but the efficacy of ulcerative colitis(UC) by fecal microbiota transplantation needs to be further explored.The investigators propose to determine the efficiency and safety of FMT in patients with ulcerative colitis(UC).

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangzhou First People's Hospital
• Treatments: Aminosalicylic Acid; Mesalamine; Prednisone

Criteria

Inclusion Criteria:

• Active, moderate to severe severity (Mayo score more than 6)

• Safety using history of 5-ASA

• Able to undergo endoscopy examination

Exclusion Criteria:

• Antibiotic using in 7 days

• High risk of toxic megacolon

• Colon cancer or neoplasia in pathophysiology

• Other severe diseases (eg: cardiovascular, respiratory, gastroenteral and kidney diseases)