Fecal Microbiota Transplantation Improves Nutritional State of Patients With Crohn's Disease

• Status: Recruiting
• Trial end date: 0000-00-00
• Target enrollment: 60
• Participant gender: Both

Summary

Patients with Crohns' disease are always complicated with malnutrition. This trial aimed to assess whether FMT accompanied by enteral nutrition (EN) can make contributions to patients with Crohns' disease.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Second Hospital of Nanjing Medical University
• Treatments: Metronidazole
• Last Updated: 2016-09-07

Criteria

Inclusion Criteria:

1. patients aged from 18 to 65, regardless of gender;

2. moderate to severe active CD patients(CDAI＞220)，accompanied with malnutrition;

3. infection status;

4. patients with high compliance;

5. suitable for fecal microbiota transplantation and enteral nutrition therapy;

6. history of safe mesalazine use.

Exclusion Criteria:

1. severe infection which affected vital signs;

2. parenteral infection such as urinary tract, lung and so on;

3. mycobacterium tuberculosis infection;

4. immunosuppressor or biologicals use within 6 week;

5. allergic to metronidazole,salicylic acid preparation, etc;

6. complicated with perianal Crohn's disease, intestinal fistula, intestinal obstruction;

7. accompanied by any severe disease such as cancer or AIDS;

8. patients who are in pregnant or going to pregnant;

9. patients who has disability mentally and physically.