Feasibility Study of Lidocaine Infusion During Bowel Cancer Surgery for Cancer Outcome

• Status: Not yet recruiting
• Trial end date: 2023-10-31
• Target enrollment: 0
• Participant gender: All

Summary

This feasibility (small) study aims to see if it is possible to run a large study looking at the effect of lidocaine on large bowel cancer recurrence after surgery in the NHS hospitals.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Imperial College London
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• Age 18 and above, undergoing laparoscopic surgery with stage 2 or 3 colon cancer

• Age 18 and above, undergoing laparoscopic surgery with stage 2 or 3 rectal cancer

• Ability and willingness to consent

Exclusion Criteria:

• Stage 1 and stage 4 colon or rectal cancer

• Palliative surgery with no curative intent

• Extensive comorbidities, i.e. American Society of Anesthesiologists (ASA) Score IV

• Patients with known or suspected allergy to lidocaine

• Patients who are currently pregnant* or breastfeeding

• Patients who are likely to have adverse effects from the accumulation of intravenous lidocaine:

• current liver disease with a liver function outside the normal laboratory range

• current renal failure (eGFR <30)

• epilepsy

• cardiac conduction abnormalities based on history and confirmed by electrocardiogram