Fatty Acid Oxidation Defects and Insulin Sensitivity

• Status: Completed
• Trial end date: 2021-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to learn more about what causes insulin resistance. It has been suggested that proper breakdown of fat into energy (oxidation) in the body is important to allow insulin to keep blood sugar in the normal range. The investigators want to know if having one of the fatty acid oxidation disorders could have an influence on insulin action. Fatty acid oxidation disorders are genetic disorders that inhibit one of the enzymes that converts fat into energy. The investigators will study both normal healthy people and people with a long-chain fatty acid oxidation disorder.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Oregon Health and Science University
• Treatments: Calcium heparin; Glycerol; Heparin; Insulin; Soybean oil, phospholipid emulsion

Criteria

Inclusion Criteria:

• confirmed diagnosis of VLCAD, LCHAD, TFP or MCAD deficiency or same gender, age and BMI as a subject with a fatty acid oxidation disorder

• ability to travel to Oregon Health & Science University, Portland, Oregon

• ability and willingness to complete the protocol

Exclusion Criteria:

• hemoglobin <10g/dl, international normalized ratio (INR) >1.2 Prothrombin time (PTT) >36 sec, Platelets <150K/mm3

• pregnant or lactating females

• endocrine disorder such as diabetes or untreated thyroid disease

• cardiovascular disease or elevated plasma lipids

• regularly taking meds that strongly affect bleeding, bruising or platelets