Overview

Fatigue in Multiple Sclerosis: Evaluated With 3 MRI and Transcranial Magnetic Stimulation

Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to investigate fatigue in patients with multiple sclerosis (MS) and to determine the correlation between the symptom and cerebral changes.
Phase:
Phase 2
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of Aarhus
Collaborator:
The Danish Multiple Sclerosis Society
Treatments:
3,4-diaminopyridine
4-Aminopyridine
Amifampridine
Criteria
Inclusion Criteria:

- Relapsing remitting-multiple sclerosis (RR-MS) according to Poser criteria

- EDSS: max 3.5

- Right handed

- Normal function of the right hand

Exclusion Criteria:

- Disease interfering with MS

- Known dementia

- Drug or alcohol abuse

- Treatment with psychoactive drugs within one week before study entry

- Major changes of medical treatment within 3 weeks before study entry

- Attack within 4 weeks before study entry

- Pregnancy

- Conditions interfering with 3,4-diaminopyridine treatment

- Conditions interfering with MRI

- Conditions interfering with transcranial magnetic stimulation