Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes
Status:
Completed
Trial end date:
2021-04-01
Target enrollment:
Participant gender:
Summary
One aim of this study is to determine changes in body composition and hormones that
differentiate athletes who stop getting their periods versus those who continue to get their
periods and non-athletes. The second aim of this study is to determine whether transdermal or
oral estrogen (versus no estrogen) is effective in increasing bone density and improving bone
microarchitecture in adolescent athletes who are not getting their periods and are thus
estrogen deficient. The investigators hypothesize that transdermal estrogen will be more
effective than oral estrogen or no estrogen in improving bone health in amenorrheic
adolescent athletes.
Phase:
Phase 3
Details
Lead Sponsor:
Massachusetts General Hospital
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)