The etiopathogenesis of ulcerative colitis (UC) is not fully understood. One of the theories
of UC pathogenesis represents a pathological response of mucosal immunity to intestinal
microbiota. Potential therapeutic procedure how to affect this fact is the faecal microbiota
transplantation (FMT). Review of the literature on FMT suggests great potential as the
treatment for UC, but two prospective controlled study that has been published yet are
inconsistent.
The first objective of the project is to compare the administration of FMT enema with
mesalazine enema for inducing remission in patients with active left-sided UC in the form of
a prospective, randomized, controlled study. The second objective is to observe changes in
the intestinal microbiota during and after FMT focusing on bacterial DNA sequencing to
identify the bacterial species which are responsible for the effect of the FMT.
Phase:
Phase 2
Details
Lead Sponsor:
Institute for Clinical and Experimental Medicine
Collaborator:
Institute of Animal Physiology and Genetics Academy of Science Czech Republic