Factors Affecting Methamphetamine and Opiates Drug Testing

• Status: Completed
• Trial end date: 2014-01-31
• Target enrollment: 0
• Participant gender: All

Summary

Background:

• Some legal over-the-counter drugs (such as Vicks VapoInhaler ) and some foods (such as poppy seeds) may cause a positive screening drug test. This might look like someone used illegal drugs (such as methamphetamines or opiates) when they did not. Researchers are studying how the body handles chemicals that may test like illegal drugs and for how long they may be detected in the body. Blood, saliva, and urine samples will be collected. This study may help improve the effectiveness and accuracy of drug tests.

Objectives:

• To see how the body handles chemicals that may produce positive screening tests and how additional testing can eliminate positive drug tests from over-the-counter drugs and food.

Eligibility:

• Healthy volunteers between 18 and 65 years of age.

Design:

• Participants are screened with a physical exam, medical history, laboratory tests, and ECG.

• This study involves an overnight stay on a secure research unit and 2 days of tests.

• On the first day, participants will take Vicks VapoInhaler (two inhalations in each nostril) every 2 hours from 9 a.m. to 7 p.m. They will also take a drink containing poppy seeds twice (at about 9 a.m. and 5 p.m.).

• On the morning of the second day, participants will take the Vicks VapoInhaler just once. They will be discharged around 5 p.m.

• On both days, participants will provide blood and saliva samples several times throughout the day. All of their urine will be collected during the 2 study days....

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Treatments: Amphetamine; Methamphetamine

Criteria

• INCLUSION CRITERIA:

• Age 18 to 65 years.

• Able to give valid informed consent.

• Able to cooperate with all study procedures.

• Peripheral venous access adequate to allow repeated blood sampling

EXCLUSION CRITERIA:

• Current medical condition that precludes safe study participation, such as 2nd or 3rd

• Current physical dependence on any psychoactive substance other than caffeine or nicotine.

degree A-V block, acute coronary syndrome, premature atrial contractions occurring more than 3/min, or premature ventricular contractions occurring more than 1/min.

• Inability to tolerate intranasal medication administration.

• Inability to safely swallow liquids containing poppy seeds.

• History of clinically significant adverse reaction to intranasal or oral decongestants.

• History of clinically significant adverse reaction to opiates.

• History of clinically significant adverse reaction from exposure (oral, inhalational, tactile) to poppy seeds, buckwheat, hazelnuts, or sesame.

• Inability to tolerate abstinence from any medication that might adversely interact with opiates, e.g., CNS depressant, systemically acting anti-cholinergic, or monoamine oxidase inhibitor.

• Women who are pregnant or nursing.

• Use, within 7 days of initial dosing with study substances, of prescription amphetamine or opiate-like substances that are related to the substances being tested.

• Internal nasal lesions that increase risk of inhalation of Vicks VaporInhaler

• Current hypertension, cardiomyopathy,or other current medical conditions associated with increased risk from adrenergic or opioid drug administration.

• Resting blood pressure consistently >140/90 mm Hg or heart rate consistently > 90 bpm

• Resting systolic blood pressure consistently < 90

• Urine drug test positive for amphetamines or opiates

• Use of a nasal decongestant or ingested an amphetamine, opiate, CNS depressant, anticholinergic, or poppy seeds within the prior week, or a monoamine oxidase inhibitor within the prior 2 weeks

• History of psychosis