FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU
Status:
Terminated
Trial end date:
2020-12-07
Target enrollment:
Participant gender:
Summary
Ischemic acute tubular necrosis (ATN) is one of the main cause of acute kidney injury (AKI)
in intensive care units (ICU). Sepsis and cardio-pulmonary bypass (CPB) are major providers.
There is no validated tool to predict the evolution of AKI is ICU. Furosemide Stress Test
(FST) may predict evolution of ATN-related AKI outside ICU in terms of progressive AKI, need
for renal replacement therapy (RRT) or inpatient mortality with improved performance
comparing to biomarkers. FST has not been validated in a prospective cohort in ICU in the
settings of ischemic ATN. FURTHER aim to determine whether FST would be a useful tool to
identify patients with slight to moderate AKI (KDIGO stage 1 and 2) who will evolve towards
need for RRT following AKIKI (The Artificial Kidney Initiation in Kidney Injury ) delayed
initiation criteria.