FRALYSE Trial: Comparison of the Classical Rt-PA Procedure With a Longer Procedure in Acute Ischemic Stroke
Status:
Terminated
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
Data from the literature have suggested that a longer time of thrombolysis might be more
effective in ischemic stroke. We, the investigators at Hospices Civils de Lyon, have designed
a randomized protocol to test this hypothesis. Moreover, the therapeutic window is 7 hours.
Rt-PA (alteplase) is injected intravenously in the 2 arms of the study for a duration of 60
minutes in the arm with a "classical dose" and 90 minutes in the arm with a "low dose-longer
infusion".
This is a study of the outcome at 90 days.