Extinction Based Treatment for Nicotine Dependence
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to test two quit smoking therapies and to study brain function
while each therapy is being used. You will be randomly assigned (like flipping a coin) to one
of the two groups. The first therapy is Extinction-Based therapy (EBT). If you are in this
group, you will switch to smoking denicotinized cigarettes while wearing a 21 mg/d nicotine
patch for one month prior to your quit date. The second therapy is a standard Nicotine
Replacement therapy (NRT). If you are in this group, you will smoke your usual brand of
cigarettes up to the quit date. Following the quit date, both groups will undergo standard
nicotine replacement therapy (21 mg/d for 6 weeks; 14 mg/d for 2 weeks, 7 mg/d for 2 weeks).
In addition to the above, we will recruit a sample of former smokers who are now regular
users of e-cigarettes. This group [ECIG] will undergo the same screening and baseline
assessments as the EBT and NRT groups up to the completion of fMRI1.