Extension Neoadjuvant Taxotere: Study of the Effects of Taxotere in Patients With Breast Cancer
Status:
Terminated
Trial end date:
2005-01-01
Target enrollment:
Participant gender:
Summary
We, the investigators at Baylor Breast Care Cancer, are doing this study to learn how well
Taxotere makes tumors become smaller. We are also doing this study to find out how well
Taxotere treats the type of breast cancer that some patients have. We are asking patients to
take part in this study because they have locally advanced breast cancer. Women with this
breast cancer will usually receive chemotherapy medicines to reduce or shrink the cancer
before surgery to take out the cancer. If patients choose to take part in this study, they
will receive Taxotere and the combination of cyclophosphamide and doxorubicin. These
medicines are part of the standard good medical care for this type of breast cancer. They are
approved for the treatment of this problem. To help us learn how the patients' cancer
responds to these medicines, we will take a small tissue sample (biopsy) of the patients'
breast cancer before beginning treatment, one day after the first dose of treatment, once
each week for the first three weeks of treatment, and when surgery is done as part of
treatment for their cancer. These samples will be collected also to look at the biology of
the patients' cancer. We will also use a new method called cDNA array technology, which lets
us look at thousands of genes (coding information inside the cancer cell) at once. By looking
at different genes in the breast cancer, we may learn important information about which
cancers will respond to a chemotherapy medicine. We hope to learn if there are different gene
patterns in patients whose tumors shrink or do not shrink with this chemotherapy medicine.
This information may help us, in the future, to choose the right medicines for women with
breast cancer so that they have the highest chance of their cancer shrinking with
chemotherapy medicine. We cannot and do not know if patients will benefit if they take part
in this study.