Extended Letrozole Regimen Versus Clomiphene Citrate for Superovulation in Patients With Unexplained Infertility Undergoing Intrauterine Insemination

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this randomized controlled trial is to compare the efficacy of extended letrozole regimen (2.5mg/day from cycle day 1 to 9) with clomiphene citrate (100 mg/day from cycle day 3 to 7) in women with unexplained infertility undergoing superovulation and intrauterine insemination .

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Collaborator: Ahmed Elgazzar Hospital
• Treatments: Chorionic Gonadotropin; Citric Acid; Clomiphene; Enclomiphene; Letrozole; Sodium Citrate; Zuclomiphene

Criteria

Inclusion Criteria:

• Patients with unexplained infertility

• Age between 18 - 37 years

• Period of infertility > 1 year

• Patent Fallopian tubes detected by hysterosalpingography and/or laparoscopy

• Normal basal luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin concentrations

• Normal recent semen analysis (according to World Health Organization criteria)

Exclusion Criteria:

• FSH> 10 IU/L

• Irregular menstrual cycles

• Polycystic ovary syndrome

• Endometriosis

• Endocrinologic disorders

• Systemic disease contraindicating pregnancy

• Previous IUI cycles

• liver or kidney diseases