Exploring the Effect of Lactate Administration After Ischemic Stroke on Brain Metabolism

• Status: Recruiting
• Trial end date: 2024-03-01
• Target enrollment: 0
• Participant gender: All

Summary

In this exploratory randomized double blind placebo controled trial, lactate solution or placebo will be administered to acute ischemic stroke patients selected for endovascular treatment (EVT) without intravenous thrombolysis. The treatment will be administered within one hour after EVT. Primary outcome measures will be lactate and metabolite concentrations in the ischemic lesion, in the penumbra and contralaterally, evaluated by magnetic resonance spectroscopy(MRS). Secondary outcome measures will be evolution of the ischemic penumbra, clinical outcome at 3 months.The trial will end when 10 patients per group have completed the study.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Universitaire Vaudois

Criteria

Inclusion Criteria:

• Acute ischemic stroke with arterial occlusion affecting middle cerebral artery (segment M1or segment 2) or internal carotid artery (T-type or L-type occlusion) selected for EVT

• not eligible for intravenous thrombolysis (IVT)

• Moderate to severe stroke (NIHSS > or = 4), and preadmission mRS > or = 3)

• Perfusion - diffusion mismatch

• Obtain consent from independent Doctor Randomisation criteria

• If possible oral consent from patient or relatives

• Treatment administration possible within 1h from EVT

Exclusion Criteria:

• Rapid neurological recovery

• Clinically unstable patient

• Contraindications to MRI

• Blood Na+ > 155 mmol/l or plasma osmolality > 320 mosmol/l

• Medical history of traumatic brain injury (TBI), neurodegenerative disease, intracranial hemorrhage, cerebral aneurysm, brain tumour

• Medical history of psychiatric disorders

• Liver insufficiency

• Heart failure

• Pregnancy (pregnancy test required in women aged under 50 unless patient or relatives indicate that the patient is not pregnant)

• Participation in another clinical trial in the last 30 days

• Lack of consent of an independent Doctor