Explore the Advantages of Remimazolam Used on Gastroscopy

• Status: Not yet recruiting
• Trial end date: 2022-08-01
• Target enrollment: 0
• Participant gender: All

Summary

There are many different types of intravenous anesthetics used in gastroscopy, but each type of drug has its advantages and disadvantages,remimazolam is a novel ultra-short-acting benzodiazepine with rapid onset and recovery, low circulatory depression, and rapid reversal of sedation by flumazenil,remimazolam may be another relatively ideal sedative-hypnotic option for anesthesiologists and gastrointestinal endoscopists. The purpose of this study was to explore whether remimazolam combined with propofol is safer and more effective than remimazolam alone or propofol alone in gastrointestinal endoscopy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sichuan Provincial People's Hospital
• Treatments: Propofol

Criteria

Inclusion Criteria:

1. Patients who are to undergo painless gastroscopy

2. Patients aged 18 - 80 years, regardless of gender

3. 18 < BMI < 30 kg/m2.

4. American Society of Anesthesiologists (ASA) classification of I-III.

Exclusion Criteria:

1. Preoperative hypertensive patients >180/110 mm Hg or hypotensive patients <80/50 mm Hg.

2. Heart rate <50 beats/min.

3. A history of acute inflammation of the respiratory tract that has not been cured within 2 weeks; severe metabolic diseases of the heart, brain, lungs, liver, kidneys and diabetes mellitus; previous heart attack, severe myocardial, ischemia, severe atrioventricular block

4. Those who may have or have had a difficult airway or a history of recovery from abnormal surgical anesthesia

5. Patients with significant electrolyte disturbances such as hyperkalemia

6. Patients with a history of long-term use of immunosuppressive agents such as hormones or adrenal cortical suppression

7. Patients with known allergy to emulsions and opioids

8. Those with combined use of other sedative and analgesic drugs within the preoperative period (including injections, oral and use of related proprietary Chinese medicines)

9. Those suspected of abusing narcotic analgesics or sedatives

10. Those who have neuromuscular system diseases, mental diseases, etc. who do not cooperate and cannot communicate.