Exploratory Study on the Therapeutic Effect Prediction Model of Advanced BTC Immunotherapy
Status:
Active, not recruiting
Trial end date:
2024-08-01
Target enrollment:
Participant gender:
Summary
1. Establish a predictive model for the efficacy of immune checkpoint inhibitors (ICI) in
Chinese patients with biliary tract cancers. By analyzing the dynamic changes of
circulating tumor DNA (ctDNA) and other clinical and pathological features before and
after ICI treatment in a cohort of patients with biliary tract tumors, a predictive
model can be established to evaluate the efficacy of ICI treatment in the early stages
or even before treatment, serving as a reliable tool for selecting patients who are
likely to benefit from ICI treatment.
2. Investigate the clinical features of populations that benefit from different immune
combination therapies. By comparing the differences and enrichment of mutations between
patients receiving different treatment regimens, and if patients have sufficient
pre-treatment tissue, further comparisons of differentially expressed genes and pathways
may be made.