Exploration of the Synovial Fluid Inflammation Mediators Under Diacerhein in Knee Osteoarthritis

• Status: Completed
• Trial end date: 2008-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis. The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its effect on other synovial inflammation mediators.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Laboratoires NEGMA
• Treatments: Diacetylrhein

Criteria

Inclusion Criteria:

• Painful osteoarthritis

• Hydarthrosis (synovial effusion)

Exclusion Criteria:

• large effusion

• severe pathologies

• anti-osteoarthritic treatments