Experimental fMRI Study of Guanfacine and Lisdexamfetamine in ADHD Adolescents
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
This is not a clinical trial. The aim of this study is to understand the mechanism of action
of two recently licensed drugs for ADHD on brain function. We will compare the brain
activation changes elicited by Guanfacine extended release (GXR; a non-stimulant drug) with
the brain activation changes elicited by Lisdexamfetamine (LISDEX; a stimulant drug) and by
placebo in 20 drug-free patients with ADHD using functional Magnetic Resonance Imaging
(fMRI). For this purpose we intend to scan participants during their performance of tasks of
attention, working memory, and inhibition, which we know from previous studies to elicit
abnormal brain activation patterns in ADHD patients (Rubia et al., 2005; Smith et al., 2006).