Experimental Studies of the Effects of Caffeine on Glucose Regulation
Status:
Completed
Trial end date:
2007-02-01
Target enrollment:
Participant gender:
Summary
This project contains experimental studies of the effects of the drug caffeine on glucose
regulation in adults who have Type 2 diabetes. In our experiments, we are testing the
hypothesis that moderate amounts of caffeine exaggerate the abnormal increases in glucose and
insulin observed after meals in patients with type 2 diabetes. On separate study days
subjects receive standard meals after taking capsules containing either caffeine or an
inactive placebo. We measure levels of glucose, insulin, and other chemicals in blood samples
drawn over the next 3 hours. In a separate study, we use continuous glucose monitoring to
measure glucose levels during everyday activities on days when subjects receive caffeine or
placebo.
These studies do not involve clinical treatment or disease management. However, we hope to
learn whether a very popular drug impairs the clinical management of a common disease.
Phase:
Early Phase 1
Details
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)